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O 2 Activation and Selective Phenolate ortho Hydroxylation by an Unsymmetric Dicopper μ‐η 1 : η 1 ‐Peroxido Complex
Author(s) -
GarciaBosch Isaac,
Company Anna,
Frisch Jonathan R.,
TorrentSucarrat Miquel,
Cardellach Mar,
Gamba Ilaria,
Güell Mireia,
Casella Luigi,
Que Lawrence,
Ribas Xavi,
Luis Josep M.,
Costas Miquel
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906749
Subject(s) - reactivity (psychology) , hydroxylation , selectivity , chemistry , tyrosinase , stereochemistry , combinatorial chemistry , oxygen atom , molecule , organic chemistry , catalysis , enzyme , medicine , alternative medicine , pathology
Unusual reactivity : A novel unsymmetric dicopper complex gives rise to the unsymmetric species 1 ‐O 2 having a μ ‐ η 1 :η 1 ‐O 2 binding mode and reactivity patterns not previously observed for symmetric analogues. It is unreactive in oxygen atom transfer reactions, but it can selectively bind phenolate and mediate its ortho hydroxylation, thereby demonstrating a conceptually different tyrosinase model with exquisite selectivity.