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Gold‐Catalyzed Halogenation of Aromatics by N ‐Halosuccinimides
Author(s) -
Mo Fanyang,
Yan Jerry Mingtao,
Qiu Di,
Li Fei,
Zhang Yan,
Wang Jianbo
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906699
Subject(s) - halogenation , catalysis , aryl , chemistry , transition metal , medicinal chemistry , organic chemistry , alkyl
Golden bromination : A highly efficient and mild AuCl 3 ‐catalyzed bromination of aromatic rings with N ‐bromosuccinimide (NBS) has been developed. This method works with a low catalyst loading (down to 0.01 mol %) and can be combined with transition metal catalyzed transformations to deliver various aryl products.