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Total Synthesis of Auripyrones A and B and Determination of the Absolute Configuration of Auripyrone B
Author(s) -
Hayakawa Ichiro,
Takemura Takuma,
Fukasawa Emi,
Ebihara Yuta,
Sato Natsuki,
Nakamura Takayasu,
Suenaga Kiyotake,
Kigoshi Hideo
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906662
Subject(s) - absolute configuration , aldol reaction , absolute (philosophy) , content (measure theory) , key (lock) , computer science , total synthesis , stereochemistry , chemistry , mathematics , philosophy , organic chemistry , epistemology , catalysis , mathematical analysis , computer security
The winner takes it al‐dol : The total synthesis of auripyrones A and B was achieved using a diastereoselective aldol‐type reaction with 2,6‐diethyl‐3,5‐dimethyl‐4‐pyrone as a key step. The stereostructure and absolute configuration of auripyrone B has also been determined.