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Enantioselective Synthesis of 2,3‐Dihydro‐1 H ‐benzo[ b ]azepines: Iridium‐Catalyzed Tandem Allylic Vinylation/Amination Reaction
Author(s) -
He Hu,
Liu WenBo,
Dai LiXin,
You ShuLi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906638
Subject(s) - allylic rearrangement , enantioselective synthesis , amination , chemistry , dabco , iridium , octane , catalysis , tandem , medicinal chemistry , styrene , stereochemistry , organic chemistry , materials science , composite material , polymer , copolymer
Making azacycles : The [{Ir(cod)Cl} 2 ]/ L complex efficiently catalyzes the tandem allylic vinylation and asymmetric allylic amination of ( E )‐ 2 with ortho ‐amino styrene derivatives 1 to afford the title compounds 3 with excellent enantioselectivity. cod=1,5‐cyclooctadiene, DABCO=1,4‐diazabicyclo[2.2.2]octane.