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Single‐Molecule Kinetics of Two‐Step Divalent Cation Chelation
Author(s) -
Hammerstein Anne F.,
Shin SeongHo,
Bayley Hagan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906601
Subject(s) - chelation , divalent , molecule , nanopore , chemistry , kinetics , combinatorial chemistry , computer science , stereochemistry , crystallography , nanotechnology , inorganic chemistry , materials science , organic chemistry , physics , quantum mechanics
A double hug : Two half‐chelating ligands were covalently attached within the lumen of a protein nanopore (see picture). By electrical recording, the formation of fully chelated Zn 2+ ions was monitored at the single‐molecule level, thus revealing the rate constants for the eight major steps in the process.