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Microparticle Matrix Encoding of Beads
Author(s) -
Meldal Morten,
Christensen Søren Flygering
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906563
Subject(s) - microparticle , encoding (memory) , polyethylene glycol , matrix (chemical analysis) , computer science , peg ratio , simple (philosophy) , microsphere , information retrieval , combinatorial chemistry , chemistry , nanotechnology , materials science , artificial intelligence , chemical engineering , engineering , chromatography , organic chemistry , philosophy , finance , epistemology , economics
Reloaded matrix : Facile optical encoding of polyethylene glycol (PEG) based resins provides a direct identification of compounds in combinatorial libraries, and the structures may be correlated with bioactivity. The new technique, microparticle matrix (MPM) encoding (see picture), circumvents some problems often encountered in solid‐phase combinatorial chemistry and is extremely simple to implement.