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A Scaffold‐Tree‐Merging Strategy for Prospective Bioactivity Annotation of γ‐Pyrones
Author(s) -
Wetzel Stefan,
Wilk Wolfram,
Chammaa Samy,
Sperl Bianca,
Roth Anke G.,
Yektaoglu Aybike,
Renner Steffen,
Berg Thorsten,
Arenz Christoph,
Giannis Athanassios,
Oprea Tudor I.,
Rauh Daniel,
Kaiser Markus,
Waldmann Herbert
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906555
Subject(s) - scaffold , schematic , identification (biology) , natural product , relevance (law) , computer science , tree (set theory) , annotation , natural (archaeology) , product (mathematics) , artificial intelligence , biology , engineering , database , mathematics , ecology , political science , mathematical analysis , biochemistry , paleontology , geometry , electronic engineering , law
Tactical target setting : The merging of natural product and non‐natural product based hierarchical scaffold trees annotated with bioactivity (see schematic illustration) together with brachiation along structural lines of biological relevance provides a novel strategy for the prospective identification of protein targets for compound collections inspired by natural product structures.