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The Synthesis of Novel Disorazoles
Author(s) -
Schäckel Romy,
Hinkelmann Bettina,
Sasse Florenz,
Kalesse Markus
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906450
Subject(s) - brother , natural product , cytotoxic t cell , chemistry , combinatorial chemistry , product (mathematics) , stereochemistry , mathematics , biochemistry , sociology , in vitro , geometry , anthropology
Big little brother : The simplified disorazole analogue 1 exhibits its cytotoxic activity at low nanomolar concentrations and provides selectivities not observed for the parent natural product.