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Sequential Five‐Component Construction of the Cyclopenta[ e ][1,3]oxazine Skeleton using Stable 2‐Azetine Derivatives
Author(s) -
Barluenga José,
Gómez Aránzazu,
Santamaría Javier,
Tomás Miguel
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906357
Subject(s) - skeleton (computer programming) , component (thermodynamics) , chemistry , computer science , physics , programming language , thermodynamics
Hawaii Five‐Oxazine : The sequential one‐pot reaction of a methoxy‐stabilized carbene with an acetylide and an imine provides stable, metal–carbene‐containing 2‐azetines. Subsequent mild treatment with an alkyne affords a regioselective, three‐component cyclization route to fully substituted fused 1,3‐oxazines.