Drug‐Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled‐Coil‐Mediated Cross‐Linking of Antigens on the Cell Surface | Zendy

Wu Kuangshi | Zendy; Liu Jihua | Zendy; Johnson Russell N. | Zendy; Yang Jiyuan | Zendy; Kopeček Jindřich | Zendy

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Drug‐Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled‐Coil‐Mediated Cross‐Linking of Antigens on the Cell Surface

Author(s) -

Wu Kuangshi,

Liu Jihua,

Johnson Russell N.,

Yang Jiyuan,

Kopeček Jindřich

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200906232

Subject(s) - pharmaceutics , pharmacy , salt lake , library science , chemistry , pharmacology , medicine , biology , family medicine , paleontology , structural basin , computer science

Peptide biorecognition : The heterodimerization of complementary randomly coiled peptides, one (red) bound to an antibody fragment (gray) and one (green) grafted to a copolymer (black), to form coiled coils resulted in the cross‐linking of CD20 target antigens (orange) on Raji B cells and consequently the initiation of apoptosis (see schematic representation).

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