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Drug‐Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled‐Coil‐Mediated Cross‐Linking of Antigens on the Cell Surface
Author(s) -
Wu Kuangshi,
Liu Jihua,
Johnson Russell N.,
Yang Jiyuan,
Kopeček Jindřich
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906232
Subject(s) - pharmaceutics , pharmacy , salt lake , library science , chemistry , pharmacology , medicine , biology , family medicine , paleontology , structural basin , computer science
Peptide biorecognition : The heterodimerization of complementary randomly coiled peptides, one (red) bound to an antibody fragment (gray) and one (green) grafted to a copolymer (black), to form coiled coils resulted in the cross‐linking of CD20 target antigens (orange) on Raji B cells and consequently the initiation of apoptosis (see schematic representation).