Premium
Enantioselective Intermolecular Aldehyde–Ketone Cross‐Coupling through an Enzymatic Carboligation Reaction
Author(s) -
Lehwald Patrizia,
Richter Michael,
Röhr Caroline,
Liu Hungwen,
Müller Michael
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906181
Subject(s) - aldehyde , enantioselective synthesis , ketone , intermolecular force , substrate (aquarium) , enzyme , chemistry , catalysis , coupling reaction , stereochemistry , acceptor , crystal structure , organic chemistry , molecule , physics , oceanography , condensed matter physics , geology
Happy new YerE : The first example of the title reaction is presented using a ThDP‐dependent enzyme catalyst. The substrate tolerance of the enzyme is very broad and includes cyclic and open‐chain ketones, as well as diketones and α‐ and β‐ketoesters as acceptor substrates. The absolute configurations of two enzymatic products were determined by single‐crystal structure analysis.