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A Diatomic Molecule Receptor That Removes CO in a Living Organism
Author(s) -
Kitagishi Hiroaki,
Negi Shigeru,
Kiriyama Akiko,
Honbo Akino,
Sugiura Yukio,
Kawaguchi Akira T.,
Kano Koji
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906149
Subject(s) - porphyrin , organism , chemistry , receptor , ligand (biochemistry) , supramolecular chemistry , cyclodextrin , molecule , biophysics , stereochemistry , biochemistry , biology , organic chemistry , genetics
A CO stripper : The O 2 ‐bound form of an iron(II) porphyrin cyclodextrin supramolecular complex (hemoCD) infused into a rat vein reacted with internal CO through ligand exchange, and the CO‐bound hemoCD was immediately excreted in the urine (see picture). The hemoCD acting as a CO receptor made it possible to quantify endogenous CO in a living organism.