Adhesion Effects of a Guanidinium Ion Appended Dendritic “Molecular Glue” on the ATP‐Driven Sliding Motion of Actomyosin | Zendy

Okuro Kou | Zendy; Kinbara Kazushi | Zendy; Takeda Kuniaki | Zendy; Inoue Yuichi | Zendy; Ishijima Akihiko | Zendy; Aida Takuzo | Zendy

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Adhesion Effects of a Guanidinium Ion Appended Dendritic “Molecular Glue” on the ATP‐Driven Sliding Motion of Actomyosin

Author(s) -

Okuro Kou,

Kinbara Kazushi,

Takeda Kuniaki,

Inoue Yuichi,

Ishijima Akihiko,

Aida Takuzo

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200906139

Subject(s) - adenosine triphosphate , actin , adenosine diphosphate , chemistry , myosin , dendrimer , biophysics , adhesion , biochemistry , biology , platelet aggregation , platelet , organic chemistry , immunology

A sticky end : A heterotropic conjugate of actin and myosin–actomysin–is stabilized by a water‐soluble dendritic “molecular glue” bearing nine pendant guanidinium ions (see picture; ATP= adenosine triphosphate, ADP=adenosine diphosphate). The ATP‐driven sliding motion of actin filaments on a myosin‐functionalized coverslip is decelerated or totally arrested with a higher‐generation dendrimer, but not with a lower‐generation one.

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