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Adhesion Effects of a Guanidinium Ion Appended Dendritic “Molecular Glue” on the ATP‐Driven Sliding Motion of Actomyosin
Author(s) -
Okuro Kou,
Kinbara Kazushi,
Takeda Kuniaki,
Inoue Yuichi,
Ishijima Akihiko,
Aida Takuzo
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906139
Subject(s) - adenosine triphosphate , actin , adenosine diphosphate , chemistry , myosin , dendrimer , biophysics , adhesion , biochemistry , biology , platelet aggregation , platelet , organic chemistry , immunology
A sticky end : A heterotropic conjugate of actin and myosin–actomysin–is stabilized by a water‐soluble dendritic “molecular glue” bearing nine pendant guanidinium ions (see picture; ATP= adenosine triphosphate, ADP=adenosine diphosphate). The ATP‐driven sliding motion of actin filaments on a myosin‐functionalized coverslip is decelerated or totally arrested with a higher‐generation dendrimer, but not with a lower‐generation one.