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Total Synthesis of Coralloidolides A, B, C, and E
Author(s) -
Kimbrough Thomas J.,
Roethle Paul A.,
Mayer Peter,
Trauner Dirk
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906126
Subject(s) - chemoselectivity , reactivity (psychology) , diene , total synthesis , stereochemistry , chemistry , organic chemistry , medicine , natural rubber , alternative medicine , pathology , catalysis
Mapping the matrix : Several coralloidolides, members of a Mediterranean branch of the furanocembranoid family of diterpenes, have been synthesized. The total syntheses include biomimetic transformations that often occur with high chemoselectivity, thus obviating the need for protecting‐group manipulations. The fascinating reactivity of 2,5‐diene‐1,4‐dione moieties was explored in detail.