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Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum
Author(s) -
Lincke Thorger,
Behnken Swantje,
Ishida Keishi,
Roth Martin,
Hertweck Christian
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906114
Subject(s) - microbiology and biotechnology , anaerobic bacteria , bacteria , clostridium , thioamide , secondary metabolite , metabolite , anaerobic exercise , chemistry , biology , biochemistry , stereochemistry , gene , physiology , genetics
Choose sulfur in an oxygen‐free world : Closthioamide ( 1 ) was isolated from the anaerobe Clostridium cellulolyticum (see SEM image) after the induction of its biosynthesis with an aqueous soil extract. An unprecedented type of symmetrical natural product in which all building blocks are connected through thioamide linkages, 1 is active against multiresistant staphylococci. It is the only known secondary metabolite from a strictly anaerobic bacterium.