Premium
Pd 0 /PR 3 ‐Catalyzed Arylation of Nicotinic and Isonicotinic Acid Derivatives
Author(s) -
Wasa Masayuki,
Worrell Brady T.,
Yu JinQuan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906104
Subject(s) - isonicotinic acid , catalysis , pyridine , chemistry , intermolecular force , nicotinic agonist , combinatorial chemistry , nicotinic acids , niacin , medicinal chemistry , organic chemistry , molecule , biochemistry , hydrazide , receptor
Good for your health : Intermolecular CH functionalization of pyridine rings at the 3‐ and 4‐positions is described using a Pd 0 /PR 3 /ArBr catalytic system. This reaction provides a powerful method for the preparation of structurally diverse nicotinic and isonicotinic acids that are of great importance in drug discovery.