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Characterization of a Ruthenium(III)/NAMI‐A Adduct with Bovine Serum Albumin that Exhibits a High Anti‐Metastatic Activity
Author(s) -
Liu Mimi,
Lim Zhi Jun,
Gwee Yee Yen,
Levina Aviva,
Lay Peter A.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906079
Subject(s) - bovine serum albumin , adduct , ruthenium , chemistry , substrate (aquarium) , albumin , serum albumin , absorption (acoustics) , stereochemistry , biochemistry , combinatorial chemistry , catalysis , organic chemistry , biology , materials science , ecology , composite material
An exchange for the better : X‐ray absorption spectroscopic studies show that treatment of an Ru III drug, NAMI‐A, with bovine serum albumin (BSA) results in complete replacement of the Cl − and S‐donor ligands with N‐donor and carboxylato residues of the protein (see scheme). The Ru III –BSA adduct is as active in enhancing the cell–substrate interactions as the original NAMI‐A complex (which converts into Ru III –BSA within minutes in the cell‐culture medium).