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General and Chemoselective N‐Transacylation of Secondary Amides by Means of Perfluorinated Anhydrides
Author(s) -
Rota Paola,
Allevi Pietro,
Colombo Raffaele,
Costa Maria L.,
Anastasia Mario
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906055
Subject(s) - chemistry , amide , hydrolysis , organic chemistry , combinatorial chemistry
A direct route : The N‐transacylation of secondary amides to their perfluorinated analogues with the possibility of subsequent conversion into a normal amide is reported (see scheme). This reaction occurs in the presence of a variety of functional groups that are labile to the hydrolysis conditions required by classical N‐transacylation.