Asymmetric Alkynylation of Imines by Cooperative Hydrogen Bonding and Metal Catalysis | Zendy

de Armas Pedro | Zendy; Tejedor David | Zendy; GarcíaTellado Fernando | Zendy

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Asymmetric Alkynylation of Imines by Cooperative Hydrogen Bonding and Metal Catalysis

Author(s) -

de Armas Pedro,

Tejedor David,

GarcíaTellado Fernando

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200906018

Subject(s) - catalysis , alkynylation , brønsted–lowry acid–base theory , organocatalysis , chemistry , metal , hydrogen bond , enantioselective synthesis , combinatorial chemistry , organic chemistry , molecule

Simple and practical : The asymmetric alkynylation of imines has been revolutionized with two nice examples of a novel model of H‐bonding asymmetric metal catalysis with Brønsted acids. The catalytic model comprises two well‐differentiated and parallel catalytic cycles: one involving metallic alkynylydes (metal catalysis) and the other one using a chiral Brønsted acid (organocatalysis; see scheme; PG=protecting group).

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