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Asymmetric Alkynylation of Imines by Cooperative Hydrogen Bonding and Metal Catalysis
Author(s) -
de Armas Pedro,
Tejedor David,
GarcíaTellado Fernando
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906018
Subject(s) - catalysis , alkynylation , brønsted–lowry acid–base theory , organocatalysis , chemistry , metal , hydrogen bond , enantioselective synthesis , combinatorial chemistry , organic chemistry , molecule
Simple and practical : The asymmetric alkynylation of imines has been revolutionized with two nice examples of a novel model of H‐bonding asymmetric metal catalysis with Brønsted acids. The catalytic model comprises two well‐differentiated and parallel catalytic cycles: one involving metallic alkynylydes (metal catalysis) and the other one using a chiral Brønsted acid (organocatalysis; see scheme; PG=protecting group).