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Desymmetrization of meso ‐2‐Alkene‐1,4‐diol Derivatives through Copper(I)‐Catalyzed Asymmetric Boryl Substitution and Stereoselective Allylation of Aldehydes
Author(s) -
Ito Hajime,
Okura Takuma,
Matsuura Kou,
Sawamura Masaya
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905993
Subject(s) - stereoselectivity , desymmetrization , substitution (logic) , copper , alkene , diol , chemistry , sequence (biology) , catalysis , chirality (physics) , stereochemistry , enantioselective synthesis , combinatorial chemistry , organic chemistry , physics , computer science , chiral symmetry breaking , quantum mechanics , quark , nambu–jona lasinio model , programming language , biochemistry
Breaking the mirror : The reaction sequence described in the title was applied to the synthesis of a valuable chiral drug precursor and the rapid stereoselective assembly of complex compounds with multiple chiral centers (see scheme).