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Decarboxylative Cross‐Coupling of Aryl Tosylates with Aromatic Carboxylate Salts
Author(s) -
Gooßen Lukas J.,
Rodríguez Nuria,
Lange Paul P.,
Linder Christophe
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905953
Subject(s) - electrophile , carboxylate , bimetallic strip , aryl , chemistry , electrophilic substitution , combinatorial chemistry , palladium , decarboxylation , catalysis , coupling (piping) , organic chemistry , materials science , alkyl , metallurgy
A bimetallic copper/palladium catalyst system is disclosed that enables the use of tosylates as carbon electrophiles in decarboxylative coupling reactions. A variety of aromatic carboxylate salts, regardless of their substitution pattern, have been coupled with these inexpensive and readily available electrophiles to give the corresponding biaryl compounds in good yields (see scheme).