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Remote Control of Regio‐ and Diastereoselectivity in the Hydroformylation of Bishomoallylic Alcohols with Catalytic Amounts of a Reversibly Bound Directing Group
Author(s) -
Grünanger Christian U.,
Breit Bernhard
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905949
Subject(s) - hydroformylation , group (periodic table) , chemistry , catalysis , control (management) , functional group , combinatorial chemistry , stereochemistry , computer science , organic chemistry , rhodium , artificial intelligence , polymer
Remote and reversible! Phosphinites serve as reversibly bound directing groups for the remote control of the regio‐ and diastereoselective hydroformylation of bishomoallylic alcohols (see scheme; r.r: regioisomer ratio). The distance between the double bond and the functional hydroxy group to which the directing group is reversibly bound is the longest ever reported.