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Lipophilic Pyridinium Bisphosphonates: Potent γ δ T Cell Stimulators
Author(s) -
Zhang Yonghui,
Cao Rong,
Yin Fenglin,
Lin FuYang,
Wang Hong,
Krysiak Kilannin,
No JooHwan,
Mukkamala Dushyant,
Houlihan Kevin,
Li Jikun,
Morita Craig T.,
Oldfield Eric
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905933
Subject(s) - pyridinium , prostate cancer , chemistry , cancer research , biochemistry , medicine , stereochemistry , cancer , medicinal chemistry
Chain gang : Lipophilic pyridinium bisphosphonates containing long alkyl chains (see picture, P red, N blue, C orange, H gray) stimulate human γδ T cells expressing the Vγ2Vδ2 T cell receptor. Stimulation with such compounds is more potent than with zoledronate, which is active against breast and prostate cancer. The lipophilic bisphosphonates bind poorly to bone and are thus less likely to cause side effects associated with bisphosphonates in clinical use.