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A Highly Sensitive, Excimer‐Controlled Molecular Beacon
Author(s) -
Häner Robert,
Biner Sarah M.,
Langenegger Simon M.,
Meng Tao,
Malinovskii Vladimir L.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905829
Subject(s) - excimer , fluorescence , molecular beacon , chromophore , chemistry , computer science , information retrieval , photochemistry , dna , physics , biochemistry , optics , oligonucleotide
Non‐nucleosidic chromophores in the stem of a molecular beacon inhibit excimer fluorescence through the formation of a donor–acceptor complex (see picture). The excellent reduction of the background fluorescence allows the detection of DNA and RNA targets in the presence of a significant excess of the probe.
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