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Direct Conversion of Arylamines to Pinacol Boronates: A Metal‐Free Borylation Process
Author(s) -
Mo Fanyang,
Jiang Yubo,
Qiu Di,
Zhang Yan,
Wang Jianbo
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905824
Subject(s) - borylation , pinacol , process (computing) , aryl , chemistry , computer science , combinatorial chemistry , catalysis , organic chemistry , programming language , alkyl
Leave the metal out : Arylboronates are produced in moderate to good yields by direct borylation of readily available aryl amines (see scheme). The reaction can be carried out under air at room temperature and transition‐metal catalysis is not required. The boronate products can be used without purification in Suzuki–Miyaura cross‐coupling reactions.