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Modeling of the 5′‐Deiodination of Thyroxine by Iodothyronine Deiodinase: Chemical Corroboration of a Selenenyl Iodide Intermediate
Author(s) -
Goto Kei,
Sonoda Daiju,
Shimada Keiichi,
Sase Shohei,
Kawashima Takayuki
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905796
Subject(s) - chemistry , deiodinase , iodothyronine deiodinase , iodide , dio2 , triiodothyronine , hormone , biochemistry , inorganic chemistry
What makes a good cavity? A molecular cavity enabled the stabilization of a selenenyl iodide (RSeI) intermediate formed in 5′‐deiodination of a thyroxine derivative by an organoselenol (see scheme). The chemical processes proposed for the iodothyronine deiodinase catalytic cycle were experimentally established.