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Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics
Author(s) -
Meindl Kathrin,
Schmiederer Timo,
Schneider Kathrin,
Reicke Andreas,
Butz Diane,
Keller Simone,
Gühring Hans,
Vértesy László,
Wink Joachim,
Hoffmann Holger,
Brönstrup Mark,
Sheldrick George M.,
Süssmuth Roderich D.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905773
Subject(s) - lantibiotics , allodynia , in vivo , chemistry , computational biology , biology , biochemistry , genetics , hyperalgesia , nisin , nociception , receptor , bacteria
A‐maze‐ing peptides : The structure of the novel lantibiotic labyrinthopeptin A2 (see picture) contains labionin—an unprecedented carbacyclic, posttranslationally modified amino acid. The identification of the biosynthetic gene cluster of labyrinthopeptins was also successful. Labyrinthopeptin A2 revealed a pronounced in vivo efficacy (attenuation of tactile allodynia) in a mouse model of neuropathic pain.