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Olefin–Oxazolines (OlefOx): Highly Modular, Easily Tunable Ligands for Asymmetric Catalysis
Author(s) -
Hahn Björn T.,
Tewes Friederike,
Fröhlich Roland,
Glorius Frank
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905712
Subject(s) - enantioselective synthesis , steric effects , ligand (biochemistry) , modular design , olefin fiber , combinatorial chemistry , chemistry , oxazoline , catalysis , conjugate , aryl , computer science , stereochemistry , organic chemistry , mathematics , programming language , mathematical analysis , biochemistry , alkyl , receptor
Foxy ligands : An efficient three‐step synthesis allows the new highly modular family of olefin–oxazoline ligands (OlefOx; see picture) to be exploited in asymmetric catalysis. The ease of electronic and steric variation and the successful application in the highly enantioselective rhodium‐catalyzed conjugate addition of aryl boronic acids to cylic enones demonstrate the importance of this new ligand class.