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DNA Analysis by Dynamic Chemistry
Author(s) -
Bowler Frank R.,
DiazMochon Juan J.,
Swift Michael D.,
Bradley Mark
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905699
Subject(s) - indel , dna , information retrieval , computational biology , mass spectrometry , computer science , chemistry , single nucleotide polymorphism , biochemistry , biology , gene , chromatography , genotype
Finding flaws : An enzyme‐free method of DNA analysis raises the possibility of analyzing single‐nucleotide polymorphism, indel, and abasic sites using mass spectrometry as a readout tool. The methodology is suitable for the dual analysis of heterozygous samples.