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Genetically Encoded Alkenes in Yeast
Author(s) -
Ai Huiwang,
Shen Weijun,
Brustad Eric,
Schultz Peter G.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905590
Subject(s) - yeast , saccharomyces cerevisiae , amino acid , transfer rna , olefin metathesis , biochemistry , computational biology , chemistry , biology , gene , metathesis , organic chemistry , rna , polymerization , polymer
Olefin‐containing amino acids have been genetically introduced into proteins in Saccharomyces cerevisiae by orthogonal tRNA/aminoacyl‐tRNA synthetase pairs. These nonnatural amino acids can be used for selective protein modification through olefin metathesis reactions.