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Histology by Mass Spectrometry: Label‐Free Tissue Characterization Obtained from High‐Accuracy Bioanalytical Imaging
Author(s) -
Römpp Andreas,
Guenther Sabine,
Schober Yvonne,
Schulz Oliver,
Takats Zoltan,
Kummer Wolfgang,
Spengler Bernhard
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905559
Subject(s) - characterization (materials science) , computer science , bioanalysis , information retrieval , mass spectrometry imaging , mass spectrometry , medical physics , computational biology , chemistry , nanotechnology , medicine , materials science , biology , chromatography
Next‐generation imaging mass spectrometry of biological tissue on the cellular level shows excellent agreement with histochemical evaluation whilst providing a much higher discrimination capacity based on label‐free molecular information (see image of a mouse urinary bladder section).