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DHTP Ligands for the Highly Ortho ‐Selective, Palladium‐Catalyzed Cross‐Coupling of Dihaloarenes with Grignard Reagents: A Conformational Approach for Catalyst Improvement
Author(s) -
Ishikawa Shunpei,
Manabe Kei
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905544
Subject(s) - palladium , catalysis , reagent , chemistry , ligand (biochemistry) , combinatorial chemistry , coupling reaction , coupling (piping) , organic chemistry , materials science , receptor , metallurgy , biochemistry
Palladium catalysts bearing dihydroxyterphenylphosphine ligands (such as 1 ) are reported for the ortho ‐selective cross‐coupling of Grignard reagents and dihaloarenes. The second hydroxy group onto the terphenylphosphine ligand dramatically improved the catalytic efficiency and expanded the scope of the reaction.