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Palladium‐Catalyzed Intramolecular Carboesterification of Olefins
Author(s) -
Li Yang,
Jardine Katherine J.,
Tan Runyu,
Song Datong,
Dong Vy M.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905478
Subject(s) - intramolecular force , vicinal , palladium , olefin fiber , catalysis , chemistry , ring (chemistry) , cycloaddition , surface modification , cascade , cascade reaction , medicinal chemistry , organic chemistry , chromatography
One catalyst, three bonds : The title reaction between propiolic acids and unactivated olefins (see scheme; O red, Cl green) results in vicinal functionalization of the olefin, with the formation of new CC and CO bonds. Structurally complex 6,7,5‐tricyclic ring systems are formed in a single step by this cascade chloropalladation and formal [3+2] cycloaddition.