Functionally Distinct Modules Operate Two Consecutive α,β→β,γ Double‐Bond Shifts in the Rhizoxin Polyketide Assembly Line | Zendy

Kusebauch Björn | Zendy; Busch Benjamin | Zendy; Scherlach Kirstin | Zendy; Roth Martin | Zendy; Hertweck Christian | Zendy

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Functionally Distinct Modules Operate Two Consecutive α,β→β,γ Double‐Bond Shifts in the Rhizoxin Polyketide Assembly Line

Author(s) -

Kusebauch Björn,

Busch Benjamin,

Scherlach Kirstin,

Roth Martin,

Hertweck Christian

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200905467

Subject(s) - moiety , domain (mathematical analysis) , stereochemistry , chemistry , computer science , mathematics , mathematical analysis

Shift work : Biochemical analysis of the rhizoxin pathway revealed that the diene moiety is not shifted all at once, but through distinct enzymatic operations. The first shift occurs by a formal β,γ‐dehydration in module 7, while the second double bond is first generated by module 8 and then shifted by an unprecedented “shift module” with a novel type of DH* domain (see scheme). ACP=acyl carrier protein, DH*=dehydratase‐like shift domain.

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