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Rhodium‐Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes
Author(s) -
Shen Xiaoqiang,
Buchwald Stephen L.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905402
Subject(s) - hydroamination , rhodium , intramolecular force , phosphine , chemistry , catalysis , cyclooctadiene , enantioselective synthesis , organic chemistry , combinatorial chemistry , medicinal chemistry
One for the Rh(oad) : The first rhodium‐catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5‐cyclooctadiene, Cy=cyclohexyl). A variety of 2‐methylpyrrolidines have been synthesized with high enantioselectivities.