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Catalytic Enantio‐ and Diastereoselective Alkylations with Cyclic Sulfamidates
Author(s) -
Moss Thomas A.,
Alonso Beatriz,
Fenwick David R.,
Dixon Darren J.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905329
Subject(s) - nucleophile , alkylation , catalysis , chemistry , ring (chemistry) , stereochemistry , combinatorial chemistry , organic chemistry
Open for business : The enantio‐ and diastereoselective nucleophilic ring opening of five‐membered and six‐membered cyclic sulfamidates under asymmetric phase‐transfer catalysis is presented. A range of pro‐nucleophiles have been successfully alkylated in good yields and in good to excellent enantioselectivites.