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Copper‐Catalyzed Azide–Alkyne Cycloaddition: Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles
Author(s) -
Spiteri Christian,
Moses John E.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905322
Subject(s) - regioselectivity , cycloaddition , azide , alkyne , combinatorial chemistry , click chemistry , catalysis , reactivity (psychology) , chemistry , computer science , organic chemistry , medicine , alternative medicine , pathology
Clicking along nicely : Few methods have been reported to be an efficient entry to trisubstituted triazoles with high regioselectivity. This challenge has inspired a search for new reactivity and the development of new chemical approaches. The development of an efficient, robust, one‐pot procedure as a route to highly decorated trisubstituted triazoles will be an added bonus to the range of click reactions (see scheme).