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Chiral Phosphoric Acid Catalyzed Desymmetrization of meso ‐1,3‐Diones: Asymmetric Synthesis of Chiral Cyclohexenones
Author(s) -
Mori Keiji,
Katoh Takuya,
Suzuki Tohru,
Noji Takuya,
Yamanaka Masahiro,
Akiyama Takahiko
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905271
Subject(s) - desymmetrization , phosphoric acid , chemistry , catalysis , enantioselective synthesis , oniom , combinatorial chemistry , organic chemistry , stereochemistry
Chiral effectiveness : The title transformation is applicable to a wide variety of substrates to give chiral cyclohexenones in high yields and with excellent enantioselectivity (see scheme). To clarify the origin of the enantioselectivity ONIOM calculations were carried out