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Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge‐Conversional Polyion Complex Micelles
Author(s) -
Lee Yan,
Ishii Takehiko,
Kim Hyun Jin,
Nishiyama Nobuhiro,
Hayakawa Yoshiyuki,
Itaka Keiji,
Kataoka Kazunori
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905264
Subject(s) - cytoplasm , micelle , cationic polymerization , intracellular , antibody , copolymer , chemistry , biophysics , cell , microbiology and biotechnology , biochemistry , biology , polymer chemistry , immunology , organic chemistry , polymer , aqueous solution
Stand and deliver! Immunoglobulin G (IgG) can be delivered into the cytoplasm of living cells by charge‐conversional modification followed by treatment with a cationic block copolymer to form polyion complex (PIC) micelles (see picture). The bioactivity of the IgG selectively recovers in the cell in a pH‐dependent manner, thereby controlling the growth of human hepatoma cells through IgG binding to intracellular target molecules.