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Targeted Optimization of a Protein Nanomachine for Operation in Biohybrid Devices
Author(s) -
AmruteNayak Mamta,
Diensthuber Ralph P.,
Steffen Walter,
Kathmann Daniela,
Hartmann Falk K.,
Fedorov Roman,
Urbanke Claus,
Manstein Dietmar J.,
Brenner Bernhard,
Tsiavaliaris Georgios
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905200
Subject(s) - microscale chemistry , computer science , movement (music) , myosin , processivity , nanotechnology , molecular motor , stability (learning theory) , human–computer interaction , materials science , chemistry , physics , biology , psychology , biophysics , dna , biochemistry , dna replication , mathematics education , acoustics , machine learning
A long life with controlled movement : Engineered protein nanomachines with defined and adjustable functional features offer opportunities for controlling movement on nano‐ to microscale biohybrid devices. Myosin motors (the picture shows a dimeric motor) have now been constructed with optimized properties with regard to stability and regulation, including switchable processivity and tight control of the velocity of movement.