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Total Synthesis of Celogentin C by Stereoselective CH Activation
Author(s) -
Feng Yiqing,
Chen Gong
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905134
Subject(s) - stereoselectivity , linkage (software) , stereochemistry , construct (python library) , total synthesis , chemistry , combinatorial chemistry , computer science , organic chemistry , gene , catalysis , programming language , biochemistry
A total gent : Inspired by the biosynthesis of celogentin C, a highly stereoselective and efficient palladium‐catalyzed CH functionalization strategy is employed to construct the key Leu‐Trp linkage of this bicyclic compound. A streamlined synthesis is completed in 23 steps from simple amino acid building blocks.