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Stereoselective Phosphine‐Catalyzed Synthesis of Highly Functionalized Diquinanes
Author(s) -
Wilson Jonathan E.,
Sun Jianwei,
Fu Gregory C.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905125
Subject(s) - stereocenter , stereoselectivity , phosphine , combinatorial chemistry , double bond , computer science , selectivity , chemistry , catalysis , organic chemistry , enantioselective synthesis
Two rings to rule them all : A versatile method has been developed for the room‐temperature synthesis of diquinanes from acyclic precursors, thereby generating two rings, three stereocenters, and a double bond with high selectivity. The products of the double cyclization can be derivatized with excellent diastereoselection into an array of highly functionalized compounds.