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Highly Stereoselective Synthesis of Monofluoroalkenes from α‐Fluorosulfoximines and Nitrones
Author(s) -
Zhang Wei,
Huang Weizhou,
Hu Jinbo
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905077
Subject(s) - stereoselectivity , chemistry , combinatorial chemistry , organic chemistry , catalysis
A fine fusion : α‐fluorosulfoximines readily react with simple nitrones to give monofluoroalkenes with excellent E / Z stereocontrol (see scheme). This novel fluoroolefination method shows promising applications in medicinal chemistry as monofluoroalkenes are potential mimetics for peptide units as protein inhibitors.