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Enantioselective Palladium‐Catalyzed Direct Arylations at Ambient Temperature: Access to Indanes with Quaternary Stereocenters
Author(s) -
Albicker Martin R.,
Cramer Nicolai
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905060
Subject(s) - stereocenter , phosphoramidite , enantioselective synthesis , palladium , chemistry , catalysis , ligand (biochemistry) , enantiomer , combinatorial chemistry , rare earth , organic chemistry , mineralogy , dna , biochemistry , receptor , oligonucleotide
Ta daa : The title reaction proceeds under essentially neutral reaction conditions at ambient temperature with a taddol‐based phosphoramidite ligand L* allowing the creation of indanes with quaternary stereogenic centers in high enantiomeric excess (see scheme; Tf=trifluoromethanesulfonyl, DMAc=dimethylacetamide).