Enantioselective Palladium‐Catalyzed Direct Arylations at Ambient Temperature: Access to Indanes with Quaternary Stereocenters | Zendy

Albicker Martin R. | Zendy; Cramer Nicolai | Zendy

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Enantioselective Palladium‐Catalyzed Direct Arylations at Ambient Temperature: Access to Indanes with Quaternary Stereocenters

Author(s) -

Albicker Martin R.,

Cramer Nicolai

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200905060

Subject(s) - stereocenter , phosphoramidite , enantioselective synthesis , palladium , chemistry , catalysis , ligand (biochemistry) , enantiomer , combinatorial chemistry , rare earth , organic chemistry , mineralogy , dna , biochemistry , receptor , oligonucleotide

Ta daa : The title reaction proceeds under essentially neutral reaction conditions at ambient temperature with a taddol‐based phosphoramidite ligand L* allowing the creation of indanes with quaternary stereogenic centers in high enantiomeric excess (see scheme; Tf=trifluoromethanesulfonyl, DMAc=dimethylacetamide).

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