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Convenient Electrophilic Fluorination of Functionalized Aryl and Heteroaryl Magnesium Reagents
Author(s) -
Yamada Shigeyuki,
Gavryushin Andrei,
Knochel Paul
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200905052
Subject(s) - electrophile , reagent , aryl , chemistry , solvent , combinatorial chemistry , magnesium , organic chemistry , computer science , catalysis , alkyl
Give me an “F” : Electrophilic fluorination of various aromatic and heteroaromatic Grignard reagents is smoothly performed with (PhSO 2 ) 2 NF as fluorinating agent in a 4:1 mixture of CH 2 Cl 2 /perfluorodecalin (see scheme). This solvent system allows minimization of most side reactions.