Hydrosilane Reduction of Tertiary Carboxamides by Iron Carbonyl Catalysts | Zendy

Sunada Yusuke | Zendy; Kawakami Hiroko | Zendy; Imaoka Tsuyoshi | Zendy; Motoyama Yukihiro | Zendy; Nagashima Hideo | Zendy

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Hydrosilane Reduction of Tertiary Carboxamides by Iron Carbonyl Catalysts

Author(s) -

Sunada Yusuke,

Kawakami Hiroko,

Imaoka Tsuyoshi,

Motoyama Yukihiro,

Nagashima Hideo

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200905025

Subject(s) - ruthenium , nitro , catalysis , chemistry , carbonyl group , carboxamide , platinum , reduction (mathematics) , combinatorial chemistry , metal carbonyl , medicinal chemistry , organic chemistry , metal , mathematics , geometry , alkyl

Fox in the carboxamide : Reduction of tertiary carboxamides to their corresponding amines is catalyzed by [Fe(CO) 5 ] or [Fe 3 (CO) 12 ], using 1,1,3,3‐tetramethyldisiloxane (TMDS) as the reducing agent. The reaction proceeds under either thermal or photochemical conditions. Unlike the hydrosilane reduction of amides using platinum or ruthenium catalysts, TMDS preferentially reduces a nitro group, even in the presence of competing amides.

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