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Iodinated Nanoscale Coordination Polymers as Potential Contrast Agents for Computed Tomography
Author(s) -
deKrafft Kathryn E.,
Xie Zhigang,
Cao Guohua,
Tran Sylvie,
Ma Liqing,
Zhou Otto Z.,
Lin Wenbin
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904958
Subject(s) - nanoscopic scale , computed tomography , contrast (vision) , polymer , ligand (biochemistry) , precipitation , microemulsion , iodinated contrast , computer science , iodine , combinatorial chemistry , phase (matter) , coordination complex , materials science , nanotechnology , metal , chemistry , chemical engineering , physics , medicine , radiology , artificial intelligence , organic chemistry , engineering , pulmonary surfactant , biochemistry , receptor , meteorology
Nanoscale coordination polymers (NCPs), prepared with metal ions and an iodinated ligand, were synthesized using reverse‐phase microemulsion techniques and rapid precipitation procedures. The NCPs carry high payloads of iodine (ca. 63 wt %) and have potential applications as a new class of contrast agents for computed tomography (CT), as demonstrated by phantom studies (see figure).