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Cover Picture: Tumor‐Associated MUC1 Tandem‐Repeat Glycopeptide Microarrays to Evaluate Serum– and Monoclonal–Antibody Specificity (Angew. Chem. Int. Ed. 44/2009)
Author(s) -
Westerlind Ulrika,
Schröder Hendrik,
Hobel Alexandra,
Gaidzik Nikola,
Kaiser Anton,
Niemeyer Christof M.,
Schmitt Edgar,
Waldmann Herbert,
Kunz Horst
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904924
Subject(s) - muc1 , glycopeptide , toxoid , tandem repeat , monoclonal antibody , antibody , computational biology , microbiology and biotechnology , biology , chemistry , immunology , antigen , genetics , genome , immunization , gene , antibiotics
A synthetic vaccine consisting of a MUC1 tandem‐repeat glycopeptide conjugated to the tetanus toxoid protein was prepared and immunized in mice. A very strong immune response with antibodies specific to the MUC1 glycopeptide was obtained, as described in the Communication by H. Kunz and co‐workers in issue 41 on page 7551 ff. To further evaluate the specificity of the antibodies from this and other synthetic vaccines, a MUC1 tandem‐repeat glycopeptide microarray platform (see cover picture) was developed by H. Kunz, H. Waldmann, and co‐workers, as reported in their Communication on page 8263 ff.