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Sodium‐Ion‐Selective Two‐Photon Fluorescent Probe for In Vivo Imaging
Author(s) -
Kim Mi Kyung,
Lim Chang Su,
Hong Jong Tae,
Han Ji Hee,
Jang HyeYoung,
Kim Hwan Myung,
Cho Bong Rae
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904835
Subject(s) - fluorescence , photon , two photon excitation microscopy , dissociation (chemistry) , in vivo , ion , intracellular , computer science , biophysics , physics , chemistry , optics , biology , genetics , biochemistry , quantum mechanics
Two photons are better than one : A two‐photon probe (ANa1, see picture) shows strong two‐photon fluorescence enhancement in response to Na + and a dissociation constant ( K d i ) of (26±2) m M in the cell. It can be easily loaded into the cells and can selectively detect intracellular free Na + in live cells and living tissues at a depth of 100–200 μm for a long period of time.
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