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Nanoscale Flexibility Parameters of Alzheimer Amyloid Fibrils Determined by Electron Cryo‐Microscopy
Author(s) -
Sachse Carsten,
Grigorieff Nikolaus,
Fändrich Marcus
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904781
Subject(s) - fibril , electron microscope , amyloid fibril , nanoscopic scale , cryo electron microscopy , biophysics , nanobiotechnology , materials science , amyloid (mycology) , crystallography , electron micrographs , microscopy , nanotechnology , chemistry , amyloid β , nanoparticle , biology , physics , optics , disease , pathology , medicine , inorganic chemistry
Versatile nanomaterial : Unusually high nanoscale flexibility was displayed by amyloid fibils in electron microscopy studies (see picture). This finding is relevant for understanding amyloid pathogenicity and for potential biotechnological applications.